background : insulin-like growth factor-1 can act in both an autocrine and paracrine manner to promote normal growth and malignant cellular proliferation. the importance of this factor as a major regulatory peptide has been established for cells, in vitro and in vivo. however, the role of serum insulin-like growth factor-1 levels in the etiology of benign prostatic hyperplasia and prostate canc...

introduction: adenotonsillar hypertrophy (ath) may present with growth retardation. insulin-like growth factor 1 (igf-1) mediates the anabolic effects of growth hormone (gh) on tissues. most of the circulating igf-1 molecules are bound to insulin-like growth factor-binding protein 3 (igfbp-3). igf-1 and igfbp-3 serum levels reflect the levels of daily mean serum gh and are used as indices for e...

background: laron syndrome, is a disease that treated by igf-1. this protein is a single chain and has three disulfide bonds. people with laron syndrome have low rates of cancer and diabetes, although they appear to be at increased risk of casual death due to their stature. igf-1 is synthesized by many tissues and is secreted from liver as an endocrine hormone which is transmitted to other tiss...

background: the aim of this study was to evaluate whether higher serum levels of insulin-like growth factor-i (igf-i) in the acute phase of ischemic stroke are associated with less severe strokes and better functional outcome in a period of 12-month follow-up. methods: from october 2014 to august 2015, patients with the diagnosis of acute ischemic stroke admitted to the stroke unit of firoozgar...

background a fall in plasma concentration of energy status related hormones (leptin, insulin-like growth factor-1 (igf-1) and insulin) and body energy expenditure occurs in response to short term fasting. nevertheless, the relations of the fasting-induced changes in energy related hormones and metabolites with fasting energy expenditure (fee) under extended fasting condition have received littl...

The insulin-like growth factor axis is highly responsive to nutritional status and may be involved as one of the underlying mechanisms through which caloric restriction could affect cancer risk. High levels of circulating insulin-like growth factor (IGF)-I, or IGF-I relative to IGF binding protein (IGFBP)-3 have been related to various human cancer types. In a group of 87 postmenopausal women, ...